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All volume data was normalized to the TIV, which is the sum of GM, WM and CSF

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Newborns (especially preterm) lack the ability to metabolize benzyl alcohol, leading to metabolic acidosis, respiratory distress, hypotension and (in reported cases) the often-fatal gasping syndrome. For this reason, only preservative-free sterile water (no benzyl alcohol) is used in pediatric or neonatal care

Biochemistry 62(3):645656

It should be noted, however, that the majority of these reports remains to be validated in additional patient cohorts and in prospective manner, which explains why none has reached clinical practice yet

Seiwerth, D